Department: HEPATO-BILIO-PANCREATIC SURGERY

TIPURI DE SERVICII OFERITE:

Operatiile efectuate in sectie fac parte cu precadere din sfera chirurgie Hepato-bilio-pancreatice precum patologia hepatica traumatica sau tumorala benigna sau maligna (primara sau secundara) si patologia pancreatica traumatica sau tumorala benigna sau maligna. Totodata sunt realizate operatii de chirurgie oncologica avansata, atat prin abord clasic cat si prin abord laparoscopic (de exemplu: chirurgie colorectala). O alta sfera de interes din cadrul sectiei o reprezinta chirurgia neoplasmelor ginecologice (uterine si ovariene), dar si a determinarilor secundare peritoneale.

In sectie sunt realizate toate operatiile chirurgicale ce vizeaza:

1. Patologia chirurgicala a sanului si a axilei.
2. Patologia chirurgicala a peretelui abdominal.
3. Patologia chirurgicala a esofagului.
4. Patologia chirurgicala a diafragmei.
5. Patologia chirurgicala a stomacului.
6. Patologia chirurgicala a ficatului.
7. Patologia chirurgicala a cailor biliare.
8. Patologia chirurgicala a splinei.
9. Patologia chirurgicala a pancreasului.
10. Patologia chirurgicala a duodenului.
11. Patologia chirurgicala a intestinului subtire.
12. Patologia chirurgicala a colonului.
13. Patologia chirurgicala a rectului.
14. Patologia chirurgicala a perineului.
15. Patologia chirurgicala a uterului.
16. Patologia chirurgicala a ovarului.
17. Patologia chirurgicala a peritoneului.
18. Patologia chirurgicala a glandei suprarenale.

DOTĂRI TEHNICE

• electrocautere mono- şi bipolare şi dispozitive de sigilare tisulară şi vasculară pentru intervenţiile clasice şi laparoscopice;
• platformă electrică COVIDIEN model ForceTriad;
• sistem de flux laminar ce permite circularea aerului conform standardelor;
• aparate portabile de aspiraţie;
• sală de operaţii în cadrul Blocului Operator Central, complet utilată, cu linie laparoscopică Storz, electrocauter ERBE şi platforma electrică Valleylab FT10;
• instrumentar chirurgical şi dotările corespunzătoare pentru intervenţiile chirurgicale clasice
• instrumentar pentru microchirurgie şi chirurgie mini-invazivă;
• instrumente pentru sutura mecanică – stapplere circulare şi lineare
• lămpi operatorii moderne;
• mese de operaţie Maquet.

ACTIVITATE ȘTIINȚIFICĂ

Membrii sectiei sunt implicati in activitatea stiintifica iar, de-alungul timpului au realizat in calitate de autori principali sau co-autori numeroase lucrari stiintifice. Amintim o parte din lucrarile reprezentative:

1. Prognostic Value of Lymph Node Ratio in Patients with Resected Synchronous Colorectal Liver Metastases and Less Than 12 Examined Lymph Nodes – Sorin Tiberiu Alexandrescu, Florin M. Selaru, Andrei S. Diaconescu, Cristian A. Zlate, Diana Blanita, Razvan T. Grigorie, Narcis O. Zarnescu, Vlad Herlea, Irinel Popescu – Journal of Gastrointestinal Surgery (2022) 26:141–149. https://doi.org/10.1007/s11605-021-05079-x
2. Aggressive surgical approach in patients with adrenal-only metastases from hepatocellular carcinoma enables higher survival rates than standard systemic therapy – Sorin T Alexandrescu, Adina E Croitoru, Razvan T Grigorie, Dana R Tomescu, Gabriela Droc, Mugur C Grasu, Irinel Popescu – Hepatobiliary & Pancreatic Diseases International (2021); 20(1), pp.28-33 https://doi.org/10.1016/j.hbpd.2020.08.008
3. Deliberate external pancreatic fistula after pancreaticoduodenectomy performed in the setting of acute pancreatitis, and its internalization through fistula-jejunostomy – Sorin T Alexandrescu, Andrei C Zlate, Razvan T Grigorie, Mihnea Ionescu, Irinel Popescu – Hepatobiliary & Pancreatic Diseases International, 2020 Feb;19(1):94-96 https://doi.org/10.1016/j.hbpd.2019.10.003
4. Influence of the Primary Tumor Location on the Pattern of Synchronous Metastatic Spread in Patients with Stage IV Colorectal Carcinoma, according to the 8th Edition of the AJCC Staging System – Sorin T. Alexandrescu, Diana T. Anastase, Razvan T. Grigorie, Cristian A. Zlate, Stefan Andrei, Radu Costea, Iulia M. Gramaticu, Adina E. Croitoru, Irinel Popescu – J Gastrointestin Liver Dis, December 2020 Vol. 29 No 4: 561-568. http://dx.doi.org/10.15403/jgld-2688
5. Safety and Efficacy of Simultaneous Resection of Gastric Carcinoma and Synchronous Liver Metastasis—A Western Center Experience – Corina-Elena Minciuna, Stefan Tudor, Alexandru Micu, Andrei Diaconescu, Sorin Tiberiu Alexandrescu* and Catalin Vasilescu – Medicina 2022, 58(12), 1802. https://doi.org/10.3390/medicina58121802 (*corresponding author)
6. The Impact of Postoperative Complications on Survival after Simultaneous Resection of Colorectal Cancer and Liver Metastases – Sorin Tiberiu Alexandrescu, Narcis Octavian Zarnescu, Andrei Sebastian Diaconescu, Dana Tomescu, Gabriela Droc, Doina Hrehoret, Vladislav Brasoveanu and Irinel Popescu – Healthcare 2022; 10(8), 1573. https://doi.org/10.3390/healthcare10081573
7. Embryologic Origin of the Primary Tumor and RAS Status Predict Survival after Resection of Colorectal Liver Metastases – Sorin Tiberiu Alexandrescu, Ioana Mihaela Dinu, Andrei Sebastian Diaconescu, Alexandru Micu, Evelina Pasare, Cristiana Durdu, Bogdan Mihail Dorobantu and Irinel Popescu – Medicina 2022, 58(8), 1100. https://doi.org/ 10.3390/medicina58081100
8. Exome sequencing identifies frequent inactivating mutations in BAP1, ARID1A and PBRM1 in intrahepatic cholangiocarcinomas – Jiao Y, Pawlik TM, Anders RA, Selaru FM, Streppel MM, Lucas DJ, Niknafs N, Guthrie VB, Maitra A, Argani P, Offerhaus GJ, Roa JC, Roberts LR, Gores GJ, Popescu I, Alexandrescu ST, Dima S, Fassan M, Simbolo M, Mafficini A, Capelli P, Lawlor RT, Ruzzenente A, Guglielmi A, Tortora G, de Braud F, Scarpa A, Jarnagin W, Klimstra D, Karchin R, Velculescu VE, Hruban RH, Vogelstein B, Kinzler KW, Papadopoulos N, Wood LD – Nat Genet. 2013 Dec;45(12):1470-3. https://doi.org/10.1038/ng.2813
9. Intrahepatic cholangiocarcinoma: an international multi-institutional analysis of prognostic factors and lymph node assessment – de Jong MC, Nathan H, Sotiropoulos GC, Paul A, Alexandrescu S, Marques H, Pulitano C, Barroso E, Clary BM, Aldrighetti L, Ferrone CR, Zhu AX, Bauer TW, Walters DM, Gamblin TC, Nguyen KT, Turley R, Popescu I, Hubert C, Meyer S, Schulick RD, Choti MA, Gigot JF, Mentha G, Pawlik TM – J Clin Oncol. 2011 Aug 10;29(23):3140-5. doi: 10.1200/JCO.2011.35.6519
10. Comparison of Hepatic Arterial Infusion Pump Chemotherapy vs Resection for Patients with Multifocal Intrahepatic Cholangiocarcinoma – Franssen S, Soares KC, Jolissaint JS, Tsilimigras DI, Buettner S, Alexandrescu S, Marques H, Lamelas J, Aldrighetti L, Gamblin TC, Maithel SK, Pulitano C, Margonis GA, Weiss MJ, Bauer TW, Shen F, Poultsides GA, Marsh JW, Cercek A, Kemeny N, Kingham TP, D’Angelica M, Pawlik TM, Jarnagin WR, Koerkamp BG JAMA Surg. 2022 Jul 1;157(7):590-596. doi: 10.1001/jamasurg.2022.1298
11. Dependency between the porosity and polymeric structure of biomaterials used in hernia surgery and chronic mesh – infection. G Pariza, CI Mavrodin, IV Antoniac. MATERIALE PLASTICE 52 (4), 484-486, 2015
12. A rare complication of CMV infection in Crohn’s disease-hemophagocytic syndrome: a case report. CS Pop, G Becheanu, D Calagiu, PV Jantea, DM Rădulescu, G Pariza, …Romanian journal of morphology and embryology= Revue roumaine de morphologie …, 2015
13. Relationship between Biomaterials Structure Used in Hernia Mesh Fixation and Chronic Infection. CI Mavrodin, VI Antoniac, G Pariza Advanced Materials Research 1114, 278-282, 2015
14. Choosing the Biomaterials for Hernia Mesh Fixation in Correlation with Surgical Procedure. G Pariza, CI Mavrodin, ME Gangone, VI Antoniac. Advanced Materials Research 1114, 253-257, 2015
15. Abdominal compartment syndrome–a major complication of large incisional hernia surgery. CI Mavrodin, G Pariza, D Ion, VI Antoniac. Chirurgia (Bucur) 108 (3), 414-447, 2013
16. [Surgical management of Meckel’s diverticulum in adults–retrospective analyses of 62 cases]. G Pariza, CI Mavrodin, M Sajin, M Ciurea. Chirurgia (Bucharest, Romania: 1990) 106 (1), 45-49, 2010
17. [Complicated Meckel’s diverticulum in adult pathology]. G Pariza, CI Mavrodin, M Ciurea. Chirurgia (Bucharest, Romania: 1990) 104 (6), 745-748, 2008
18. [Late pancreatic metastasis from primary Grawitz tumor–surgical management]. D Ion, M Sajin, N Copcă, G Pariza, CI Mavrodin, M Ciurea. Chirurgia (Bucharest, Romania: 1990) 104 (1), 105-107, 2008
19. [General principles of abdominal wall reconstruction–20 years of experience]. M Ciurea, D Ion, G Pariza, CI Mavrodin. Chirurgia (Bucharest, Romania: 1990) 103 (2), 211-217, 2007
20. Popescu GA, Alexandrescu ST, Grigorie RT, Stoica L, Apavaloaie CA, Hrehoreţ D. GOOD TO KNOW: The ALPPS Procedure – Embracing a New Technique. Chirurgia (Bucur). 2017 May-Jun;112(3):332-341. doi: 10.21614/chirurgia.112.3.332. PMID: 28675369.
21. C.Aliuș, M.Zivari, D. Dumitrescu, A. Cursaru, B. Serban. Non operative management of blunt splenic injuries beyond safety conditions. A short narative review.Romanian Journal of Orthopaedic Surgery and Traumatology.2021 4 (1) :46-52
22. C .Aliuș, N Bacalbașa, C Bălălău. Innovative Device for Indocianyne Green Navigational Surgery. Journal of Mind and Medical Sciences. 2020 7 (1), 40-45
23. Alius, C.; Tudor, C.; Badiu, C.D.; Dascalu, A.M.; Smarandache, C.G.; Sabau, A.D.; Tanasescu, C.; Balasescu, S.A.; Serban, D. Indocyanine Green-Enhanced Colorectal Surgery—between Being Superfluous and Being a Game-Changer. Diagnostics 2020, 10, 742.
24. A.Cotiga, M.Zivari, A. Cursaru, C. Alius. Amputations, psychological consequences and quality of life among Romanian patients. Romanian Journal of Orthopaedic Surgery and Traumatology. 2020 ;3(1):29-40
25. Serban, D.; Smarandache, C.G.; Tudor, C.; Duta, L.N.; Dascalu, A.M.; Aliuș, C. Laparoscopic Surgery in COVID-19 Era—Safety and Ethical Issues. Diagnostics 2020, 10, 673
26. Adrian Dumitru et al. Posttraumatic intraosseous epidermoid inclusion cyst. A case report and short literature review. Romanian Journal of Orthopaedic Surgery and Traumatology 2020; 3(1):3-8
27. Minodora O, Ana-Maria V, Iuliana I, Horia B, Adriana N, Cătălin A et al. Pregnancy-Associated Gastric Cancer: Real-Life Diagnosis and Management . Pharmacophore 2020;11(3):89-92
28. Minodora Onisâi et al. Synchronous Multiple Breast Cancers—Do We Need to Reshape Staging? Medicine. 2020 56 (5), 230
29. A Dumitru, C Aliuş, AE Nica, I Antoniac, D Gheorghiță, S Grădinaru Fatal outcome of gastric perforation due to infection with Sarcina spp. A case report. IDCases 2020 19, e00711
30. Dan DUMITRESCU, Costel SAVLOVSCHI, Sorin OPRESCU, Dragos SERBAN, Sebastian GRADINARU, Tiberiu TROTEA, Bogdan SOCEA, Catalin ALIUS, Victor DUMITRESCU. A rare complication of acute appendicitis–case presentation. Arch Balk Med Union. 2019 54(1):196-199
31. C Alius, C Balalau, D Dumitrescu, S Gradinaru. Essentials of surgical anatomy and technique in TAPP repair of inguinal hernia. Journal of Clinical and Investigative Surgery .2018 3 (2), 66-71
32. C. ALIUS, ES GRADINARU, AE NICA. Indocyanine Green Fluorescence in Surgical Practice-A Narrative Review of Clinical Applications.Romanian Journal of Medical Practice. 2017 12 (2)
33. C Alius, ES Gradinaru, AE Nica INDOCYANINE GREEN ENHANCED  LAPAROSCOPIC CHOLECYSTECTOMY IN ACUTE PATIENTS: DO WE NEED A REVISION OF THE SAFETY PARADIGMS? Romanian Medical Journal 2017 64 (2)
34. C Alius, S Oprescu, C Balalau, AE Nica Indocyanine green enhanced surgery; principle, clinical applications and future research directions Journal of Clinical and Investigative Surgery .2018 3(1), 1-8 15. A EL-KHATIB, C Alius, D Serban ENDOSCOPIC TREATMENT FOR UPPER GI BLEEDING. REVALIDATION OF FORREST CLASSIFICATION. Romanian Medical Journal 64 (2)
35. A El-Khatib, C Alius, D Serban NON-VARICEAL UPPER GASTROINTESTINAL BLEEDING RECENT GUIDELINES, RISK STRATIFICATION AND PARADIGMS.Romanian Medical Journal 64 (1)
36. Iulia Soreaţă, C. Şavlovschi, R. Borcan, H. Panţu, C. Brănescu, Anca Lungu, C. Aliuş, S. Grădinaru Postoperative Adhesions Sindrome-Risk Factors.Chirurgia, 2010, 105, 1 (S): 182 (ISSN 1221-9118)
37. Peritoneal Adhesions- The main source for postoperative morbidity . Costel Savlovschi, Dragos Serban, Horia Pantu, Gabriel Smarandache, C. Alius, Sebastian Gradinaru-Fometescu, Cristian Branescu, Meda Comandasu, Florin Tiuca, Camelia Gavan, Sorin Oprescu. Chirurgia, 2008, 103, 1 (S): 39 (ISSN 1221-9118)

Activitatea didactica a sectiei cuprinde pregătirea chirurgicală a studenţilor din anul IV şi V, Facultatea de Medicină, UMF “Carol Davila” Bucureşti si pregătirea profesională chirurgicală a medicilor rezidenţi.